‘Signal’ For Major Birth Defects Seen In Lyrica Cohort Study

(May 20, 2016, 2:01 PM EDT) -- MINNEAPOLIS — A study published in the May 18 issue of the medical journal Neurology found a signal for increased risk of major birth defects after first-trimester exposure to the anti-epileptic drug Lyrica.

Researchers in Switzerland conducted a multicenter, observational prospective cohort study that compared 165 pregnant women who took Lyrica (pregabalin) with 656 matched control women who were not exposed to any anti-epileptic drugs or drugs known to be teratogenic.

The researchers said their study is limited by a small sample size, by differences across...
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